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Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation.

Cell death & disease - 13 Jun 2018

Li Run-Ze, Fan Xing-Xing, Duan Fu-Gang, Jiang Ze-Bo, Pan Hu-Dan, Luo Lian-Xiang, Zhou Yan-Ling, Li Ying, Yao Ying-Jia, Yao Xiao-Jun, Leung Elaine Lai-Han, Liu Liang

Abstract excerpt

Non-small-cell lung cancer (NSCLC) is the predominant histological type of lung cancer and is characterized by the highest mortality and incidence rates among these types of malignancies. Cardiac glycosides, a class of natural products, have been identified as a potential type of chemotherapeutic agent. This study aims to investigate the anti-cancer effects and the mechanisms of action of Proscillaridin A (P.A)...

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Identifiers

PMID: 29899551
DOI: 10.1038/s41419-018-0733-4
PMCID: PMC5999972

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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