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Article

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells.

Journal of cellular and molecular medicine - 1 Jan 2021

Gao Feng, Li Ming, Yu Xinfang, Liu Wenbin, Zhou Li, Li Wei

Abstract excerpt

Dysfunction of epidermal growth factor receptor (EGFR) signalling plays a critical role in the oncogenesis of non-small-cell lung cancer (NSCLC). Here, we reported the natural product, licochalcone A, exhibited a profound anti-tumour efficacy through directly targeting EGFR signalling. Licochalcone A inhibited in vitro cell growth, colony formation and in vivo tumour growth of either wild-type (WT) or activating...

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Identifiers

PMID: 33247550
DOI: 10.1111/jcmm.16135
PMCID: PMC7812290

Genes

EGFR

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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