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Article

Germline Telomere-Regulating Gene Variants Are Not Associated with Thyroid Cancer in a Saudi Arabian Population.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2025

Alzahrani Ali S, Alsaihati Burair, Benito Allianah, Alghamdi Balgees, Alhamoudi Kheloud M, Alsaud Arwa, Altuwaijri Norah, Alhossiny Midrar, Alfares Ahmed, Murugan Avaniyapuram Kannan

Abstract excerpt

Background: Germline variants in the telomere-regulating genes (TRG) of the shelterin complex have recently been associated with long telomere length and increased risk of several tumors, including thyroid cancer (TC). We aimed to validate these findings in a different ancestral population. Patients and Methods: We conducted a cross-sectional study in a tertiary care hospital in Saudi Arabia. We included 189...

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PMID: 41153079
DOI: 10.1177/10507256251388092

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TRG
ACD
TERT

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