Genetic haplotypes in VWA8, OSBPL6, and ADAMTS9-AS2 are associated with immune-related adverse effects in ICI-treated patients with cancer.

doi:10.1136/jitc-2025-012012

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Article

Genetic haplotypes in VWA8, OSBPL6, and ADAMTS9-AS2 are associated with immune-related adverse effects in ICI-treated patients with cancer.

Journal for immunotherapy of cancer - 28 Oct 2025

Raj Prithvi, Liu Jialiang, Zhu Chengsong, Arana Carlos, J Fattah Farjana, Mu-Mosley Hong, Switzer Benjamin, Park Jason Y, von Itzstein Mitchell S, Wakeland Edward K, Puzanov Igor, Zakharia Yousef, Daniels Gregory A, Shaheen Montaser F, Xie Yang, SoRelle Jeffrey A, Gerber David E

Abstract excerpt

BACKGROUND: Immune-related adverse events (irAEs) remain largely unpredictable, potentially affecting multiple organ systems and occurring at almost any point during and even occasionally after immune checkpoint inhibitor (ICI) treatment. To identify populations at risk for these immune-mediated toxicities, we analyzed genetic characteristics and immune markers associated with clinically significant irAEs....

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Topics

Humans
Male
Female
Neoplasms
Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Aged

ADAMTS9 Protein

Immune Checkpoint Inhibitors

Polymorphism, Single Nucleotide

Genome-Wide Association Study

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 41151836
DOI: 10.1136/jitc-2025-012012
PMCID: PMC12570911

Genes

ADAMTS9
OSBPL6
VWA8
CCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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