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Article

Association between germ-line HLA and immune-related adverse events

13 Sept 2022

Abstract excerpt

Background In recent years, significant progress has been made in immune checkpoint inhibitors (ICIs). However, accompanied by remarkable efficacy, a growing number of immune-related adverse events (irAEs) also arose. The mechanism of irAEs remains unclear. Previous studies indicated a positive association between specific human leukocyte antigen (HLA) variants and irAEs. Therefore, we planned and initiated a...

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PMID: 36177028
DOI: 10.3389/fimmu.2022.952099

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