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Article

The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study.

Frontiers in immunology - 1 Jan 2022

He Di, Liu Liyang, Shen Dongchao, Zou Peng, Cui Liying

Abstract excerpt

Objectives: Multiple sclerosis (MS) is a complex central nervous system (CNS) demyelinating disease, the etiology of which involves the interplay between genetic and environmental factors. We aimed to determine whether genetically predicted peripheral immune cell counts may have a causal effect on MS. Methods: We used genetic variants strongly associated with cell counts of circulating leukocyte, lymphocyte,...

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Identifiers

PMID: 35619713
DOI: 10.3389/fimmu.2022.867693
PMCID: PMC9128528

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