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Article

P2X7 receptor contributes to DNA damage repair and acquisition of malignant phenotypes in irradiated human glioblastoma cells.

Biochimica et biophysica acta. General subjects - 1 Dec 2025

Seki Hiromu, Kitabatake Kazuki, Uchiumi Fumiaki, Tanuma Sei-Ichi, Tsukimoto Mitsutoshi

Abstract excerpt

Radiation therapy for cancer takes advantage of the higher sensitivity of tumor cells to radiation compared to normal tissue, but some cancers, such as glioblastoma (GBM) and malignant melanoma, acquire radiation resistance (radioresistance), rendering treatment ineffective. Radioresistance is characterized by strong activation of DNA repair mechanisms in response DNA damage induced by radiation, together with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41135637
DOI: 10.1016/j.bbagen.2025.130873

Genes

HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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