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Article

Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species

10 Sept 2015

Abstract excerpt

Glioblastoma multiforme (GBM) is among the most lethal of human malignancies. Most GBM tumors are refractory to cytotoxic therapies. Glioma stem cells (GSCs) significantly contribute to GBM progression and post-treatment tumor relapse, therefore serving as a key therapeutic target; however, GSCs are resistant to conventional radiation therapy. Proton therapy is one of the newer cancer treatment modalities and its...

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PMID: 26354413
DOI: 10.1038/srep13961

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