Article
Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders.
Human genetics - 1 Feb 2014
Ligthart Lannie, Hottenga Jouke-Jan, Lewis Cathryn M, Farmer Anne E, Craig Ian W, Breen Gerome, Willemsen Gonneke, Vink Jacqueline M, Middeldorp Christel M, Byrne Enda M, Heath Andrew C, Madden Pamela A F, Pergadia Michele L, Montgomery Grant W, Martin Nicholas G, Penninx Brenda W J H, McGuffin Peter, Boomsma Dorret I, Nyholt Dale R
Abstract excerpt
Migraine and major depressive disorder (MDD) are comorbid, moderately heritable and to some extent influenced by the same genes. In a previous paper, we suggested the possibility of causality (one trait causing the other) underlying this comorbidity. We present a new application of polygenic (genetic risk) score analysis to investigate the mechanisms underlying the genetic overlap of migraine and MDD. Genetic...
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