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Article

Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG.

Molecular psychiatry - 1 Mar 2026

Spielman Benjamin, Bagnall-Moreau Ciara, Chen Frank, Balvuena Crystal, Cruz Christian, Carrion Joseph, Vo An, Arazi Arnon, Brimberg Lior

Abstract excerpt

Microglia play a crucial role in brain development, including synaptic pruning and neuronal circuit formation. Prenatal disruptions, such as exposure to maternal autoantibodies, can dysregulate microglial function and contribute to neurodevelopmental disorders like autism spectrum disorder (ASD). Maternal antibodies targeting the brain protein Caspr2, encoded by ASD risk gene Cntnap2, are found in a subset of...

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Identifiers

PMID: 41131280
DOI: 10.1038/s41380-025-03298-1
PMCID: PMC12916316

Genes

ACE
CA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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