Article

Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

2025-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Maternal anti-Caspr2 (Contactin-associated protein-like 2) antibodies have been associated with increased risk for autism spectrum disorder (ASD). Previous studies have shown that in utero exposure to anti-Caspr2 antibodies results in a phenotype with ASD-like features in male mice. Here we ask whether four newly generated antibodies against Caspr2 are pathogenic to the developing fetal brain a...

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Literature Corpus work: 829b95ae-10fd-5e81-8167-2e9012ad4bf0
DOI: 10.1101/2025.01.16.633238

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