Emerging integrase strand transfer inhibitor drug resistance mutations among children and adults on ART in Tanzania: findings from a national representative HIV drug resistance survey.

doi:10.1093/jac/dkad010

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Emerging integrase strand transfer inhibitor drug resistance mutations among children and adults on ART in Tanzania: findings from a national representative HIV drug resistance survey.

The Journal of antimicrobial chemotherapy - 2 Mar 2023

Kamori Doreen, Barabona Godfrey, Rugemalila Joan, Maokola Werner, Masoud Salim S, Mizinduko Mucho, Sabasaba Amon, Ruhago George, Sambu Veryeh, Mushi Jeremiah, Mgomella George S, Mcollogi James J, Msafiri Frank, Mugusi Sabina, Boniface Jullu, Mutagonda Ritah, Mlunde Linda, Amani Davis, Mboya Erick, Mahiti Macdonald, Rwebembera Anath, Ueno Takamasa, Pembe Andrea, Njau Prosper, Mutayoba Beatrice, Sunguya Bruno

Abstract excerpt

BACKGROUND: Despite the scale-up of ART and the rollout in Tanzania of dolutegravir, an integrase strand transfer inhibitor (INSTI), treatment success has not been fully realized. HIV drug resistance (HIVDR), including dolutegravir resistance, could be implicated in the notable suboptimal viral load (VL) suppression among HIV patients. OBJECTIVES: To determine the prevalence and patterns of acquired drug...

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PMID: 36680436
DOI: 10.1093/jac/dkad010

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