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Article

Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance.

Nature communications - 6 Sept 2018

Tiku Varnesh, Kew Chun, Mehrotra Parul, Ganesan Raja, Robinson Nirmal, Antebi Adam

Abstract excerpt

Innate immunity is the first line of defense against infections. Pathways regulating innate responses can also modulate other processes, including stress resistance and longevity. Increasing evidence suggests a role for the nucleolus in regulating cellular processes implicated in health and disease. Here we show the highly conserved nucleolar protein, fibrillarin, is a vital factor regulating pathogen resistance....

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Identifiers

PMID: 30190478
DOI: 10.1038/s41467-018-06051-1
PMCID: PMC6127302

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