Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans.

PLoS genetics - 1 Apr 2025

Tecle Eillen, Warushavithana Paaramitha, Li Samuel, Blanchard Michael J, Chhan Crystal B, Bui Theresa, Underwood Ryan S, Bakowski Malina A, Troemel Emily R, Lažetić Vladimir

Abstract excerpt

Robust transcriptional responses are critical for defense against infection. However, unrestrained immune responses can cause negative impacts such as damaging inflammation and slowed development. Here, we find that a class of transcriptional regulators previously associated with regulation of development in Caenorhabditis elegans, is also involved in repressing immune responses. Specifically, through forward...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Chromatin Assembly and Disassembly

Share to Gene Expression Regulation

Share to Immunity, Innate

Share to Repressor Proteins

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 40193347
DOI: 10.1371/journal.pgen.1011444
PMCID: PMC11975079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans.PMID 40193347Read ↗

The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the <i>C. elegans</i> intestineSemantic proximity Read ↗

The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine.Semantic proximity Read ↗

Dynamic Control of Argonautes by a Rapidly Evolving Immunological SwitchSemantic proximity Read ↗

A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans.Semantic proximity Read ↗

A novel N6-Deoxyadenine methyltransferase METL-9 modulates C. elegans immunity via dichotomous mechanismsSemantic proximity Read ↗

Role of ZIP‐10 in the Regulation of innate Immunity in <em>Caenorhabditis elegans</em> During Pathogenic InfectionSemantic proximity Read ↗

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegansSemantic proximity Read ↗

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.Semantic proximity Read ↗

MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegansSemantic proximity Read ↗

A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegansSemantic proximity Read ↗

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogasterSemantic proximity Read ↗

Identification of innate immunity genes and pathways using a comparative genomics approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.