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Article

Dabrafenib plus trametinib vs encorafenib plus binimetinib in BRAF-mutant metastatic melanoma: a real-world propensity score-matched survival analysis.

Journal of the National Cancer Institute - 1 Feb 2026

Garitaonaindia Yago, Khan Shawez, Friis Rasmus, Kjær Søren, Borch Troels H, Ruhlmann Christina, Guldbrandt Louise M, Luczak Adam A, Schmidt Henrik, Bastholt Lars, Svane Inge Marie, Donia Marco, Ellebaek Eva

Abstract excerpt

BACKGROUND: Encorafenib is a BRAF inhibitor with a pharmacodynamic profile distinct from that of dabrafenib, including a longer dissociation half-life that may enable more sustained BRAF inhibition. It has been hypothesized that this could translate into superior clinical efficacy. We aimed to determine whether encorafenib plus binimetinib is superior to dabrafenib plus trametinib in terms of clinical activity...

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PMID: 41110839
DOI: 10.1093/jnci/djaf263

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BRAF

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