COLUMBUS 7-year update: A randomized, open-label, phase III trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF V600E/K-mutant melanoma.

doi:10.1016/j.ejca.2024.114073

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COLUMBUS 7-year update: A randomized, open-label, phase III trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF V600E/K-mutant melanoma.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2024

Schadendorf Dirk, Dummer Reinhard, Flaherty Keith T, Robert Caroline, Arance Ana, de Groot Jan Willem B, Garbe Claus, Gogas Helen J, Gutzmer Ralf, Krajsová Ivana, Liszkay Gabriella, Loquai Carmen, Mandalà Mario, Yamazaki Naoya, Queirolo Paola, Guenzel Carolin, Polli Anna, Thakur Mahgull, di Pietro Alessandra, Ascierto Paolo A

Abstract excerpt

BACKGROUND: Treatment with encorafenib plus binimetinib and encorafenib monotherapy is associated with improved progression-free survival (PFS) and overall survival (OS) compared with vemurafenib in patients with BRAF V600E/K-mutant metastatic melanoma. We report results from the 7-year analysis of COLUMBUS part 1 (NCT01909453) at 99.7 months (median duration between randomization and data cutoff). METHODS: 577...

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PMID: 38723373
DOI: 10.1016/j.ejca.2024.114073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COLUMBUS 7-year update: A randomized, open-label, phase III trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF V600E/K-mutant melanoma.PMID 38723373Read ↗

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