Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

doi:10.1016/S1470-2045(18)30142-6

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Article

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

The Lancet. Oncology - 1 May 2018

Dummer Reinhard, Ascierto Paolo A, Gogas Helen J, Arance Ana, Mandala Mario, Liszkay Gabriella, Garbe Claus, Schadendorf Dirk, Krajsova Ivana, Gutzmer Ralf, Chiarion-Sileni Vanna, Dutriaux Caroline, de Groot Jan Willem B, Yamazaki Naoya, Loquai Carmen, Moutouh-de Parseval Laure A, Pickard Michael D, Sandor Victor, Robert Caroline, Flaherty Keith T

Abstract excerpt

BACKGROUND: Combined BRAF-MEK inhibitor therapy is the standard of care for BRAFV600-mutant advanced melanoma. We investigated encorafenib, a BRAF inhibitor with unique target-binding properties, alone or in combination with the MEK inhibitor binimetinib, versus vemurafenib in patients with advanced BRAFV600-mutant melanoma. METHODS: COLUMBUS was conducted as a two-part, randomised, open-label phase 3 study at...

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PMID: 29573941
DOI: 10.1016/S1470-2045(18)30142-6

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.PMID 29573941Read ↗

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