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IL-21 gene polymorphism is associated with the prognosis of breast cancer in Chinese populations.

Breast cancer research and treatment - 1 Feb 2013

You Yonghe, Deng Jieqiong, Zheng Jian, Hu Min, Li Na, Wu Hongchun, Li Wei, Lu Jiachun, Zhou Yifeng

Abstract excerpt

Interleukin (IL)-21, which is secreted by activated CD4(+) T cells and NKT cells, has been found to be able to influence the humoral and cell-mediated immune responses and have potent antitumor activity in animal models. This study was to investigate the impact of genetic polymorphisms in IL-21 on survival of breast cancer. Four TagSNPs of IL-21 (rs12508721C>T, rs907715G>A, rs13143866G>A, rs2221903A>G) were...

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PMID: 23288348
DOI: 10.1007/s10549-012-2401-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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