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Article

Surfactant proteins A and D nucleotide variants: association with retinal vascular disease.

Pediatric research - 1 Jun 2026

Allen Kelsey Brass, Rousselle Dustin, Aston Christopher E, Montañez Keishla Colón, Silveyra Patricia, Chen Wen, Eckert Jeffrey, Siatkowski Raymond Michael, Vitiello Peter F, Bhatti Faizah N

Abstract excerpt

BACKGROUND: Retinopathy of prematurity (ROP) is associated with systemic inflammation. Surfactant proteins A and D (SP-A and SP-D) play an immunomodulatory role. We previously reported the impact of SP-A on retinal angiogenesis. This study investigates SP-A and SP-D single-nucleotide polymorphisms (SNPs) with risk of ROP. METHODS: Subjects were infants with gestational age (GA) of <32 weeks and/or birth weight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pulmonary Surfactant-Associated Protein A

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Source

Open in PubMed Open full text

Identifiers

PMID: 41102472
DOI: 10.1038/s41390-025-04435-w
PMCID: PMC12600029

Genes

IMPACT
SFTPA1
SFTPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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