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Article

Impact of TMPRSS6 Genetic Variants on Maternal Iron Status in Pregnancy: A Systematic Review.

Birth defects research - 1 Oct 2025

Fauzan Rezky, Defrin, Susmiati, Lipoeto Nur Indrawaty

Abstract excerpt

OBJECTIVE: The TMPRSS6 gene encodes matriptase-2, a serine protease that negatively regulates hepcidin and thus governs systemic iron homeostasis. Common polymorphisms have been implicated in altered iron indices in normal populations. To date, no systematic review has comprehensively assessed the impact of TMPRSS6 on maternal iron status and pregnancy outcomes. This review aims to elucidate the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41097872
DOI: 10.1002/bdr2.2538

Genes

TMPRSS6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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