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Genetic analysis of TMPRSS6 gene in Saudi female patients with iron deficiency anemia.

Hematology/oncology and stem cell therapy - 1 Mar 2021

Al-Jamea Lamiaa H, Woodman Alexander, Heiba Nihal Mohamed, Elshazly Shereen A, Khalaf Noureddine Ben, Fathallah Dahmani M, Al-Nashmi Moudi E, Quiambao Jenifer Vecina, Deifalla Abdel Halim

Abstract excerpt

OBJECTIVE/BACKGROUND: Mutations in transmembrane protease serine 6 (TMPRSS6) gene induce high hepcidin level, which causes iron-refractory iron deficiency anemia (IRIDA) by preventing duodenal iron absorption. This study aims to identify the common genetic variations of the TMPRSS6 gene that affect iron levels among Saudi female patients with iron deficiency anemia (IDA). METHODS: All study participants were...

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PMID: 32446932
DOI: 10.1016/j.hemonc.2020.04.007

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