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Article

The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia.

Gene - 5 Oct 2018

Batar Bahadir, Bavunoglu Isil, Hacioglu Yalcin, Cengiz Mahir, Mutlu Tuba, Yavuzer Serap, Yavuzer Hakan, Cuhadar Ercelebi Dilek, Erhan Duygu, Unal Selin, Tunckale Aydin, Guven Mehmet

Abstract excerpt

TMPRSS6 gene mutations can result in iron deficiency anemia (IDA) and cause an increased iron-regulatory hormone, hepcidin, levels. TMPRSS6 encodes a serine protease, matriptase-2, which functions as negative regulatory protein of hepcidin transcription. Thus, TMPRSS6 variations might be risk factors for IDA. The aim of the study was to investigate the association of rs855791, rs4820268, rs5756506, rs2235324,...

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Share to Anemia, Iron-Deficiency
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Source

Identifiers

PMID: 29928945
DOI: 10.1016/j.gene.2018.06.055

Genes

TMPRSS6

Provenance

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