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Article

Bacterial Systematic Genetics and Integrated Multi-Omics: Beyond Static Genomics Toward Predictive Models.

International journal of molecular sciences - 24 Sept 2025

Sakaguchi Tatsuya, Irifune Yuta, Kamada Rui, Sakaguchi Kazuyasu

Abstract excerpt

The field of bacterial systems biology is rapidly advancing beyond static genomic analyses, and moving toward dynamic, integrative approaches that connect genetic variation with cellular function. This review traces the progression from genome-wide association studies (GWAS) to multi-omics frameworks that incorporate transcriptomics, proteomics, and interactome mapping. We emphasize recent breakthroughs in...

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PMID: 41096595
DOI: 10.3390/ijms26199326
PMCID: PMC12524605

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