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Genetically predicted causal links between gut microbiota and biological aging phenotypes in age-related macular degeneration.

Biogerontology - 13 Oct 2025

Zhou Yifan, Wang Zhenyu, Huang Chen, Yu Xiaotong, Cai Xueyao, Zhao Di, Cai Yuchen

Abstract excerpt

Current knowledge regarding the role of gut microbiota (GM) dysbiosis and biological aging in the pathogenesis of age-related macular degeneration (AMD) remains limited. This study aims to explore the causal relationships among these factors in AMD development. Utilizing two-sample bidirectional mendelian randomization (MR), we analyzed genome-wide association study (GWAS) data from 105,248 individuals, including...

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PMID: 41081949
DOI: 10.1007/s10522-025-10329-5

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