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Article

Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study.

Archives of gerontology and geriatrics - 1 Apr 2025

Zhang Guolin, Lu Yuqing, Wang Zhen, Ma Ruicong, Jin Hongjin, Zhang Jingsi, Liu Fengyi, Ding Yanchun

Abstract excerpt

INTRODUCTION: Observational studies and clinical trials have suggested a connection between gut microbiota and aging. However, the causal relationship between them remains undetermined. OBJECTIVES: This study aimed to use bidirectional two-sample Mendelian randomization (TSMR) analysis to explore the causal relationship between gut microbiota and aging. METHODS: Summary statistics from genome-wide association...

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Identifiers

PMID: 39988416
DOI: 10.1016/j.archger.2025.105765

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