Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder.

doi:10.1038/s41588-022-01143-7

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Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder.

Nature genetics - 1 Aug 2022

Rajagopal Veera M, Duan Jinjie, Vilar-Ribó Laura, Grove Jakob, Zayats Tetyana, Ramos-Quiroga J Antoni, Satterstrom F Kyle, Artigas María Soler, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Als Thomas D, Rosengren Anders, Daly Mark J, Neale Benjamin M, Nordentoft Merete, Werge Thomas, Mors Ole, Hougaard David M, Mortensen Preben B, Ribasés Marta, Børglum Anders D, Demontis Ditte

Abstract excerpt

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with onset in childhood (childhood ADHD); two-thirds of affected individuals continue to have ADHD in adulthood (persistent ADHD), and sometimes ADHD is diagnosed in adulthood (late-diagnosed ADHD). We evaluated genetic differences among childhood (n = 14,878), persistent (n = 1,473) and late-diagnosed (n = 6,961) ADHD cases...

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Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder.

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