Article
The relative contribution of common and rare genetic variants to ADHD.
Translational psychiatry - 10 Feb 2015
Martin J, O'Donovan M C, Thapar A, Langley K, Williams N
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD) is highly heritable. Genome-wide molecular studies show an increased burden of large, rare copy-number variants (CNVs) in children with ADHD compared with controls. Recent polygenic risk score analyses have also shown that en masse common variants are enriched in ADHD cases compared with population controls. The relationship between these common and rare variants...
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