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Article

Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis.

Clinical and experimental immunology - 21 Jan 2025

Moundir Abderrahmane, Aissaoui Ouissal, Akhrichi Nassima, Allaoui Abire, Benhsaien Ibtihal, Jouanguy Emmanuelle, Casanova Jean-Laurent, El Bakkouri Jalila, Ailal Fatima, Bousfiha Ahmed Aziz

Abstract excerpt

Increasing evidence supports the involvement of inborn errors of immunity in severe infections, but little is known about the prevalence of these genetic defects in children with sepsis. Due to the limited understanding of the molecular and immunological mechanisms driving sepsis, genetic testing is rarely used in routine diagnostics to identify genetic susceptibility to the condition. We performed a prospective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39918293
DOI: 10.1093/cei/uxaf007
PMCID: PMC11966105

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