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Article

Determining targets for ceftriaxone resistance detection in Neisseria gonorrhoeae based on genotype-phenotype data: an observational study.

The Lancet. Microbe - 1 Nov 2025

van Hal Sebastiaan J, Lahra Monica M, Whiley David M

Abstract excerpt

BACKGROUND: Increasing antimicrobial resistance to ceftriaxone in Neisseria gonorrhoeae presents a public health crisis. We aimed to identify a target associated with ceftriaxone resistance to support the development of rapid diagnostic tests. METHODS: In this observational study, we included N gonorrhoeae isolates with linked penA (NEIS1753) locus and ceftriaxone minimum inhibitory concentration (MIC) data. We...

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PMID: 41075810
DOI: 10.1016/j.lanmic.2025.101199

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