Article
Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene.
Molecular brain - 9 Oct 2025
Khan Abdul Aziz, Wang Shuai, Wang Ziying, Rehman Zainab, Chen Lei, Kuang Yifang, Zhang Xu, Li Yuting, Yang Jiarun, Ye Jun, Ma Xianda, Zhao Qian, Ding Ying, Suzuki Tatsuo, Lan Zhaohui, Li Weidong
Abstract excerpt
The ErbB4 gene is a schizophrenia (SCZ) risk gene that interacts with PSD-95 via its C-terminus, a connection disrupted in SCZ patients. To investigate the functional significance of this interaction, we generated a zygotic mutant mouse lacking the terminal valine "V" residue from the ErbB4 TVV motif. The homozygous (homo) mice exhibited disrupted ErbB4‒PSD-95 interactions and SCZ-relevant behavioral deficits,...
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