Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia.

doi:10.1002/ajmg.b.30236

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Article

Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2006

Norton Nadine, Moskvina Valentina, Morris Derek W, Bray Nicholas J, Zammit Stanley, Williams Nigel M, Williams Hywel J, Preece Anna C, Dwyer Sarah, Wilkinson Jennifer C, Spurlock Gillian, Kirov George, Buckland Paul, Waddington John L, Gill Michael, Corvin Aiden P, Owen Michael J, O'Donovan Michael C

Abstract excerpt

There is now strong evidence that Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. NRG1 mediates some of its effects through the tyrosine kinase receptor erbB4, and analysis of gene knock-out animals suggests that the functional interaction of NRG1 and erbB4 mediates behaviors that may model some aspects of the schizophrenia phenotype in mice. Given these findings, we have sought evidence for...

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PMID: 16249994
DOI: 10.1002/ajmg.b.30236

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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