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Article

SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism.

Journal of the American College of Cardiology - 24 May 2011

McNair William P, Sinagra Gianfranco, Taylor Matthew R G, Di Lenarda Andrea, Ferguson Debra A, Salcedo Ernesto E, Slavov Dobromir, Zhu Xiao, Caldwell John H, Mestroni Luisa

Abstract excerpt

OBJECTIVES: The aim of this study was to discern the role of the cardiac voltage-gated sodium ion channel SCN5A in the etiology of dilated cardiomyopathy (DCM). BACKGROUND: Dilated cardiomyopathy associates with mutations in the SCN5A gene, but the frequency, phenotype, and causative nature of these associations remain the focus of ongoing investigation. METHODS: Since 1991, DCM probands and family members have...

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Source

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Identifiers

PMID: 21596231
DOI: 10.1016/j.jacc.2010.09.084
PMCID: PMC9689753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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