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Article

Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis.

EMBO reports - 1 Nov 2025

Zhang Yi, Shen Lei, Ren Lili, Wei Jiangbo, Pham Hoang Quoc Hai, Tao Xiaoqun, Guo Jiamin, Wang Zhihao, Shen Binghui, Su Rui, He Chuan, Yang Yanzhong

Abstract excerpt

N6-methyladenosine (m6A) homeostasis is essential for development, and its dysregulation is linked to cancers and neurological disorders. However, the mechanisms regulating m6A remain unclear. Here, we identify the survival of motoneuron (SMN) protein as a novel interaction partner of METTL14, a key component of the m6A methyltransferase complex. SMN binds METTL14 via its Tudor domain in an arginine...

Read the complete abstract on PubMed

Topics

Methyltransferases
Animals
Arginine
Humans
Methylation
Mice
Homeostasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adenosine

Fibroblasts

Muscular Atrophy, Spinal

Mutation

Protein Binding

Disease Models, Animal

Survival of Motor Neuron 1 Protein

DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 41053315
DOI: 10.1038/s44319-025-00590-7
PMCID: PMC12635257

Genes

METTL14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis.PMID 41053315Read ↗

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