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Article

A novel function for the survival motoneuron protein as a translational regulator

6 Nov 2012

Abstract excerpt

SMN1, the causative gene for spinal muscular atrophy (SMA), plays a housekeeping role in the biogenesis of small nuclear RNA ribonucleoproteins. SMN is also present in granular foci along axonal projections of motoneurons, which are the predominant cell type affected in the pathology. These so-called RNA granules mediate the transport of specific mRNAs along neurites and regulate mRNA localization, stability, as...

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PMID: 23136128
DOI: 10.1093/hmg/dds474

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