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Article

SMN controls neuromuscular junction integrity through U7 snRNP

1 Sept 2022

Abstract excerpt

The neuromuscular junction (NMJ) is an essential synapse whose loss is a key hallmark of the neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that activity of the SMA-determining SMN protein in the assembly of U7 small nuclear ribonucleoprotein (snRNP)-which functions in the 3'-end processing of replication-dependent histone mRNAs-is required for NMJ integrity. Co-expression of U7-specific...

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PMID: 36130491
DOI: 10.1016/j.celrep.2022.111393

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