Article
Significance of GNAS mutations for morbid obesity in children.
Human genomics - 30 Sept 2025
Salakhov Ramil R, Khusainova Rita I, Vasyukova Olga V, Kopytina Daria A, Yalaev Bulat I, Karpova Yulia S, Okorokov Pavel L, Peterkova Valentina A, Minniakhmetov Ildar R, Mokrysheva Natalia G
Abstract excerpt
BACKGROUND: Hereditary forms of obesity are characterized by early severe heterogeneous manifestations of the phenotype along with a rapid progression to morbid obesity, primary due to pathogenic variants of certain genes. Most forms are characterized by moderate to severe neuropsychic developmental delays, dysmorphic features and organ-specific developmental anomalies. RESULT: We searched for hereditary causes...
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- Humans
- Chromogranins
- GTP-Binding Protein alpha Subunits, Gs
- Child
- Obesity, Morbid
- Male