Functional mutations in the thyroid-stimulating hormone receptor in natural stickleback populations at sites identical to human disease-causing mutations.

doi:10.1186/s12862-025-02440-5

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Article

Functional mutations in the thyroid-stimulating hormone receptor in natural stickleback populations at sites identical to human disease-causing mutations.

BMC ecology and evolution - 30 Sept 2025

Kitano Jun, Sato Mana, Kanbe Hiyu, Okude Genta, Ishikawa Asano, Kazeto Yukinori, Makino Takashi

Abstract excerpt

BACKGROUND: Thyroid hormones regulate multiple physiological functions, including metabolism, reproduction, and metamorphosis. Although there are variations in thyroid hormone signaling between populations and species, the causative mutations underlying these variations have rarely been identified. Here, we investigated whether information regarding the causative genes and mutations responsible for human thyroid...

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PMID: 41029246
DOI: 10.1186/s12862-025-02440-5
PMCID: PMC12481769

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