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Article

Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism.

Scientific reports - 20 Nov 2024

Hiron Thomas K, Aguiar Joana, Williams Jonathan M, Falcone Sara, Norman Paul A, Elliott Jonathan, Fowkes Robert C, Syme Harriet M, Davison Lucy J

Abstract excerpt

Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited. However, FHT shares clinical and histopathological similarities with human toxic multinodular goitre, which has been associated with activating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gs

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Identifiers

PMID: 39567583
DOI: 10.1038/s41598-024-79564-z
PMCID: PMC11579033

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