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Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398.

Molecular & cellular proteomics : MCP - 1 Dec 2018

Busche Tobias, Hillion Mélanie, Van Loi Vu, Berg David, Walther Birgit, Semmler Torsten, Strommenger Birgit, Witte Wolfgang, Cuny Christiane, Mellmann Alexander, Holmes Mark A, Kalinowski Jörn, Adrian Lorenz, Bernhardt Jörg, Antelmann Haike

Abstract excerpt

The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and surface-associated adhesins allowing host adaptation and colonization. Here, we combined proteogenomics, secretome and phenotype analyses to compare the secreted virulence factors in selected S. aureus...

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Identifiers

PMID: 30201737
DOI: 10.1074/mcp.RA118.001036
PMCID: PMC6283302

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