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Article

Essential Staphylococcus aureus toxin export system.

Nature medicine - 1 Mar 2013

Chatterjee Som S, Joo Hwang-Soo, Duong Anthony C, Dieringer Thomas D, Tan Vee Y, Song Yan, Fischer Elizabeth R, Cheung Gordon Y C, Li Min, Otto Michael

Abstract excerpt

Widespread antibiotic resistance among important bacterial pathogens such as Staphylococcus aureus calls for alternative routes of drug development. Interfering with crucial virulence determinants is considered a promising new approach to control bacterial infection. Phenol-soluble modulins (PSMs) are peptide toxins with multiple key roles in pathogenesis and have a major impact on the ability of highly virulent...

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Identifiers

PMID: 23396209
DOI: 10.1038/nm.3047
PMCID: PMC3594369

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