Article
Genotype-by-sex interaction analyses for alcohol use disorder across biobanks.
Alcohol, clinical & experimental research - 1 Nov 2025
Zhou Hang, Wang Lu, Mao Zhongzheng, Deans P J Michael, Kember Rachel L, Chen Qingyu, Zakiniaeiz Yasmin, Kohler Robert, Peltier MacKenzie R, Verplaetse Terril L, Potenza Marc N, Brennand Kristen J, Justice Amy C, Kranzler Henry R, Gelernter Joel, McKee Sherry A
Abstract excerpt
BACKGROUND: Alcohol use and alcohol use disorder (AUD) are significant contributors to morbidity and mortality, with different prevalences between males and females. Despite the established genetic contribution to AUD, sex as a biological variable and the interplay with genetic factors in the disorder remain largely unexplored. This study aimed to address the key question as to how genetic variations interact...
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