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Integrated Microfluidic System for Rapid 89-Plex Y-SNP Profiling: Development and Forensic Validation.

Electrophoresis - 1 Oct 2025

Li Yongjie, Jiang Li, Liu Qingyang, Chen Boxu, Zhuang Bin, Zhao Lijian, Han Junping, Li Caixia

Abstract excerpt

Current Y-chromosomal single-nucleotide polymorphism (Y-SNP) detection technologies in forensic genetics often rely on bulky equipment, complex procedures, and lack adaptability to field conditions. To address these limitations, we developed an 89-plex microfluidic Y-SNP system comprising a disposable DNA extraction/amplification chip and a capillary electrophoresis chip. Using in situ lyophilization, the...

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PMID: 41017288
DOI: 10.1002/elps.70029

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