Article
Integrated Microfluidic System for Rapid 89-Plex Y-SNP Profiling: Development and Forensic Validation.
Electrophoresis - 1 Oct 2025
Li Yongjie, Jiang Li, Liu Qingyang, Chen Boxu, Zhuang Bin, Zhao Lijian, Han Junping, Li Caixia
Abstract excerpt
Current Y-chromosomal single-nucleotide polymorphism (Y-SNP) detection technologies in forensic genetics often rely on bulky equipment, complex procedures, and lack adaptability to field conditions. To address these limitations, we developed an 89-plex microfluidic Y-SNP system comprising a disposable DNA extraction/amplification chip and a capillary electrophoresis chip. Using in situ lyophilization, the...
Topics
- Polymorphism, Single Nucleotide
- Humans
- Chromosomes, Human, Y
- Forensic Genetics
- Electrophoresis, Capillary
- Microfluidic Analytical Techniques
- Reproducibility of Results
- DNA
- Male
- Genotyping Techniques