Article
Development and validation of a 365-Plex NGS panel for integrated Y-STR and Y-SNP typing: Enhancing paternal lineage analysis in Chinese populations.
Forensic science international - 1 Apr 2026
Li Min, Yu Xue, Zhao Weizhu, Cai Guofang, Zhou Peng, Yu Chunjiang, Meng Deping, Wei Ran, Xu Xiaoqun, Yan Jiangwei, Zhou Song, Fang Chen
Abstract excerpt
In forensic genetics, Y-chromosomal short tandem repeats (Y-STRs) and single nucleotide polymorphisms (Y-SNPs) are indispensable for paternal lineage identification and population genetic research. While Y-STRs enable short-term familial linkage, their high mutation rates complicate precise lineage determinations. Conversely, Y-SNPs provide stable deep phylogenetic resolution, complementing Y-STRs by resolving...
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