Article
Development and validation of a STR and SNP multiplex detection system (88 STRs and 348 SNPs) using massively parallel sequencing.
International journal of legal medicine - 1 Mar 2026
Lu Yanfang, Yang Fan, Liu Yanan, Xuan Yujia, Zhao Jinyuan, Liao Mengxiao, Xing Yu, Liu Sitong, Zhang Suhua, Chen Anqi
Abstract excerpt
Short tandem repeats (STRs) have long been the gold standard in forensic DNA analysis, while single nucleotide polymorphisms (SNPs) have increasingly emerged as valuable complementary markers. The advent of massively parallel sequencing (MPS) technology has significantly enhanced the detection resolution of both STRs and SNPs, providing novel approaches for forensic human identification. In this study, we...
Topics
- Humans
- Polymorphism, Single Nucleotide
- Microsatellite Repeats
- High-Throughput Nucleotide Sequencing
- DNA Fingerprinting
- Genotype
- Male
- Electrophoresis, Capillary
- Female
- Sequence Analysis, DNA
- DNA Degradation, Necrotic
- Multiplex Polymerase Chain Reaction