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Microhaplotype and Y-SNP/STR (MY): A novel MPS-based system for genotype pattern recognition in two-person DNA mixtures.

Forensic science international. Genetics - 1 Jul 2022

Fan Haoliang, Xie Qiqian, Wang Lingxiang, Ru Kai, Tan Xiaohui, Ding Jiuyang, Wang Xiao, Huang Jian, Wang Zhuo, Li Yanning, Wang Xiaohan, He Yitong, Gu Cihang, Liu Min, Ma Shiwen, Wen Shaoqing, Qiu Pingming

Abstract excerpt

BACKGROUNDS: Y-chromosomal haplotypes based on Y-short tandem repeats (STRs) and Y-single nucleotide polymorphisms/insertion and deletion polymorphisms (SNPs/InDels) are used to characterize paternal lineages of unknown male trace donors. However, Y-chromosomal genetic markers are not currently sufficient for precise individual identification. Microhaplotype (MH), generally < 200 bp on autosomes and consisting of...

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PMID: 35462161
DOI: 10.1016/j.fsigen.2022.102705

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