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Article

Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome.

Genes, chromosomes & cancer - 1 May 2014

Volkert Sarah, Kohlmann Alexander, Schnittger Susanne, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

We analyzed 1,200 patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) harboring a 5q deletion in order to clarify whether the type of 5q loss is associated with other biological markers and prognosis. We investigated all patients by chromosome banding analysis, FISH with a probe for EGR1 (5q31) and, if necessary, to resolve complex karyotypes with 24-color-FISH. Moreover, 420 patients...

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Share to Abnormal Karyotype
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 5

Share to Clonal Evolution

Share to Early Growth Response Protein 1

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Translocation, Genetic

Source

Identifiers

PMID: 24493299
DOI: 10.1002/gcc.22151

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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