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Article

Classification based on tumor phenotypes enables the novel molecular characterization of esophagogastric junction cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Nov 2025

Takahashi Kyota, Hatakeyama Keiichi, Terashima Masanori, Nagashima Takeshi, Urakami Kenichi, Ohshima Keiichi, Ochiai Atsushi, Shimoda Tadakazu, Koseki Yusuke, Furukawa Kenichiro, Fujiya Keiichi, Tanizawa Yutaka, Tsubosa Yasuhiro, Bando Etsuro, Kanai Yae, Akiyama Yasuto, Yamaguchi Ken

Abstract excerpt

BACKGROUND: The incidence of esophagogastric junction (EGJ) cancer is increasing worldwide. Siewert type II EGJ cancer encompasses intestinal and gastric phenotypes; however, the molecular profiles and clinicopathological features remain unclear. METHODS: Overall, 922 patients who underwent surgical resection for EGJ or gastric cancer from 2014 to 2023 were analyzed. The tumors were classified into intestinal and...

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Identifiers

PMID: 40999183
DOI: 10.1007/s10120-025-01665-z

Genes

NOX1
TP53
CD4

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