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Integrative proteomic characterization of adenocarcinoma of esophagogastric junction

11 Feb 2023

Abstract excerpt

The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics and phosphoproteomics profiling of 103 AEG tumors with paired normal adjacent tissues (NATs), whole exome sequencing of 94 tumor-NAT pairs, and RNA sequencing in 83 tumor-NAT pairs. Our analysis reveals an...

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PMID: 36774361
DOI: 10.1038/s41467-023-36462-8

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