Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila.

Abstract excerpt

Evolutionary theory suggests that lifespan-reducing alleles should be purged from the gene pool, and yet decades of genome-wide association and model organism studies have shown that they persist. One potential explanation is that alleles that regulate lifespan do so only in certain environmental contexts. We exposed outbred Drosophila to control and high-sugar diets and genotyped more than 10,000 adult flies to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diet
• Share to Drosophila
• Share to Drosophila melanogaster