Article

Rare Coding Variation Identified by Whole-Exome Sequencing in Multiple Sclerosis: A Systematic Review of Candidate Genes, Replication, and Evidence Strength

2026-08-28

Abstract excerpt

Genome-wide association studies have identified more than 200 common-risk loci for multiple sclerosis (MS), but common variants do not fully explain familial aggregation. Whole-exome sequencing (WES) has therefore been applied to multiplex families and clinical cohorts to identify rare protein-altering variants. We systematically searched five databases from inception to 10 August 2026, supplemented by citation se...

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Literature Corpus work: 9e378f41-ba82-5c22-8fee-66d9457f87d3
DOI: 10.20944/preprints202608.2146.v1

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